Protein Localization with Flexible DNA or RNA

Protein Localization with Flexible DNA or RNA

Localization of activity is ubiquitous in life, and also within sub-cellular compartments. Localization provides potential advantages as different proteins involved in the same cellular process may supplement each other on a fast timescale. It might also prevent proteins from being active in other regions of the cell. However localization is at odds with the spreading of unbound molecules by di...

DNA / RNA Sequences Protein Sequences

Many scientiic disciplines (e.g., biology, astrophysics, particle physics, earth sciences) are shifting from in vitro to in silico research as more physical processes and natural phenomena are simulated in a computer (in silico) instead of being observed (in vitro). In many of these virtual laboratories, the computations involved are very complex and long lived. Currently, users are required to...

Dendritic Cell Maturation and Activation via RNA/DNA Danger Signals: Co-delivery of Protein Antigen with siRNA or CpG DNA

Multiple RNA binding protein complexes interact with the rice prolamine RNA cis-localization zipcode sequences.

RNAs for the storage proteins, glutelins and prolamines, contain zipcode sequences, which target them to specific subdomains of the cortical endoplasmic reticulum in developing rice (Oryza sativa) seeds. Fifteen RNA binding proteins (RBPs) specifically bind to the prolamine zipcode sequences and are likely to play an important role in the transport and localization of this storage protein RNA. ...

DIBER: protein, DNA or both?

The program DIBER (an acronym for DNA and FIBER) requires only native diffraction data to predict whether a crystal contains protein, B-form DNA or both. In standalone mode, the classification is based on the cube root of the reciprocal unit-cell volume and the largest local average of diffraction intensities at 3.4 A resolution. In combined mode, the Phaser rotation-function score (for the 3.4...